Assessing mortality projections or estimates based on catastrophic events, such as emerging infectious diseases, mass-casualty terrorism, natural hazards, pandemics, can be exceptionally difficult. Take a pandemic for example, in today’s interconnected world a disease can spread extremely rapid and cause unimaginable losses in terms of economics and above all human health and life. At Infinite Observations we take into consideration various sources of uncertainty, which means explicitly capturing population spatial and temporal dynamics, varying availability and efficacy of medical interventions due to patient age and health, the availability of healthcare, economic resources, etc., which result in a probabilistic solution.  Morbidity and mortality are quantified by converting into economic losses by applying appropriate constraints. Infinite Observations Mortality Projection models can be validated entirely or as individual components. They are validated against loss data from multiple historic events, and , and other (inter-)national and local health agencies such as World Health Organization, the United States Centers for Disease Control and Prevention (CDC), the European Centre for Disease Prevention and Control (ECDC).